The actor, who portrays Peter Barlow in the Weatherfield-based soap, told TV Times magazine that Danson's portrayal of Peter's wife Leanne has raised the bar for her fellow 'Best Dramatic Performance' nominees.
Gascoyne and Danson have been at the centre of a number of dramatic storylines this year, including being caught up in the devastation of the show's 50th anniversary tram crash.
Danson was later voted by her fellow cast mates as the best actress in the live episode.
"Jane upped the game this year, massively. I can honestly say, she's possibly the best actress that I've ever worked with," Gascoyne said.
He continued: "I love to come into work and do scenes with her because we never know what's going to happen. She always gets left out of everything, but this year she isn't, and I think people recognise how good she is."
Danson was similarly supportive of Gascoyne, who is up for the 'Best Actor' honour at this week's awards.
"I think Chris is one of the best actors in soap, period, whether he's got good stuff to do or he's just going to the shop for a pint of milk," she explained.
The British Soaps Awards ceremony will take place in Manchester on May 14.