According to The Sun, the 63-year-old actress recently filmed her final scenes as glamorous hairdresser Claudia Colby.
An ongoing plot has seen Claudia confide in her friend Audrey Roberts (Sue Nicholls) her suspicions that her boyfriend Marc Selby (Andrew Hall) is having an affair, unaware of his cross-dressing secret. However, viewers saw Marc unveil his alter ego Marcia to a shocked Claudia last week.
Her departure will reportedly allow Audrey and Marc to begin a relationship, with the new couple tipped to share their first kiss in July.
"We're really going to have some fun with this," an insider told the paper. "Audrey will fully embrace Marc's cross-dressing, and even help him pick out outfits."
However, Lenska - who will tour the UK with the stage production of Calendar Girls from August - has asked bosses to leave the door open for her to return to the Manchester serial.
A spokeswoman for the soap said: "We've loved having Rula. She's been absolutely brilliant as Claudia and we hope one day she'll return."
Coronation Street producer Phil Collinson previously spoke out to dismiss rumours that Claudia was being lined up as the next landlady of the Rovers Return.
> Nicholls: 'Lenska a dream to work with'