The actress announced the news on This Morning today, confirming that the blaze will tie in with the forthcoming departure of her character Cheryl Gray.
Cheryl is currently in a relationship with Weatherfield cabbie Lloyd Mullaney (Craig Charles), but her old spark with former partner Chris Gray (Will Thorp) has recently been reignited following his brain tumour diagnosis.
Earlier this year, it emerged that Cheryl, Chris and their son Russ will all be written out of the show as the storyline reaches its conclusion.
Teasing Cheryl's departure, Quin-Ankrah commented: "It's not too predictable. It might not be exactly how you expect it to be.
"There is a fire - it's dramatic! Something goes on fire - that's quite exciting."
Quin-Ankrah added that Cheryl will not be killed off in the blaze, leaving the door open for a possible return.
Reflecting on her time at Coronation Street, she continued: "It's been amazing. It's been an amazing experience, I've been really happy there. [I've been there] for 20 months, just under two years, and it's been fab.
"When I started, you don't know long you're staying. You think you're going to be there six months and that's it, so it's lovely."
Rival soap EastEnders has also been tipped to air a fire storyline before the end of the year.
> Coronation Street Chris leaves with a bang, says Will Thorp
> Read more Coronation Street news and spoilers
Watch a video preview of Friday night's Coronation Street double bill below: