Speaking in an interview with RTÉ, the 37-year-old actor said that the show's bosses have assured him that he can reprise his role as Ciaran McCarthy at any time.
"It's very much open," he said. "The producers said that while they understood my family commitments in Ireland, they told me to remember that there was always a job for me on the Street."
The Boyzone singer has previously insisted that he will rejoin the soap.
Since announcing his departure, it has been reported that Duffy will soon star in an Irish theatre show.
Duffy's alter ego Ciaran, who arrived back on the Street with fiancé Michelle Connor last Thursday, is being written out in a dramatic Christmas storyline.
> Coronation Street's Kym Marsh: 'I will miss Keith Duffy'