The actor recently finished filming a brief return stint in the role of Ciaran McCarthy after deciding that he needs to be back home with his family in Ireland this year.
Keith and his wife Lisa are parents to 15-year-old Jay and 11-year-old Mia, who has autism.
Reflecting on his choice to bow out from Coronation Street, Duffy told The Sun: "It wasn't an easy decision. I sat down with my wife Lisa and she said, 'Keith, I really need you here and the kids need you here'.
"Mia is autistic and very set in her ways. Routine is vital in her life. And it's my son's first year of major exams at school. He's doing the equivalent of his GCSEs this year. Lisa does the rugby run, swimming run, ballet run and school run for the kids. She has been brilliant but, at the same time, the kids need their daddy around.
"Moving the family over to England from Dublin wasn't an option just yet because Mia needs to finish her school year where she is at the moment. So I came in to see the Coronation Street producers and explained I was going to have to sit this year out in Ireland."
He added: "Hopefully, if they want me back the following year, then I might consider relocating the family to the UK next summer. They were very supportive, so we'll see what happens."
Coronation Street viewers will see Ciaran decide to leave the cobbles next week.
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