Kelly filmed her final scenes for the ITV1 soap late last year and fans will see her alter ego Becky McDonald bow out from the cobbles in a week's time.
Lane's character Kylie, meanwhile, will be sticking around in Weatherfield for the foreseeable future as her married life with David Platt (Jack P Shepherd) continues.
Discussing Kelly's departure, Lane told The Mirror: "I have had a good 12 months to get used to the idea. I have known pretty much since I started, but I do feel that Katherine has taught me a lot and there is no point in being upset about it.
"She has made such a mark on this show, it just inspires me to achieve the same things that she has."
The actress added that Kylie has mixed feelings as Becky's exit storyline unfolds on screen.
"She is thrilled for Becky, but when it happens it is a massive shock to her," Lane confirmed.
Coronation Street continues tonight at 7.30pm and 8.30pm on ITV1.
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Watch a preview of tonight's Coronation Street double bill in the video below: