Frank, played by Andrew Lancel, is found lying dead in a pool of his own blood at Underworld next week - following days of arguments and confrontations with associates, lovers and enemies alike.
In the weeks that follow, police and local residents start pointing the finger of blame at five characters who all had their own motives - Michelle, Peter, Carla, Kevin and Sally.
As the police investigation intensifies, an arrest will finally be made - but fans will be left to wonder whether the authorities have caught the right person or if the real killer has got away with murder.
Before Frank is killed, viewers will see him con Carla out of her share in the factory - not content with being acquitted of raping her. His latest stunt makes him a hate figure in Weatherfield, which means the mystery of his murder is all the more difficult to solve.
Sally Dynevor, who plays Sally Webster, commented: "Sally's got lots of reasons to want to do something very bad to Frank, as have all the factory staff as he was plotting for them all to lose their jobs. But there's a particular motive for Sally because of the way he betrayed her on a personal level and the way she was prepared to betray her friends for him."
Of Peter Barlow's motive, actor Chris Gascoyne explained: "On a scale of one to ten, Peter hates Frank 11 - for what he's done to Carla and the fact that he's still trying to ruin both their lives. When he double crosses Carla at the factory, that's just another reason for Peter to really hate him. He wants him dead."
Michael Le Vell said of Kevin Webster: "He claims not to have gone anywhere near Frank before he was killed, but there's a twist which makes him a suspect. It throws Kevin Webster right in the frame and the police come calling."
Finally, Kym Marsh - who plays Michelle Connor - said: "Michelle's always been a very moral person. Having said that, her big thing is family and she's very protective of the Connor clan. Frank destroyed Carla, so maybe Michelle decided to dish out some justice of her own. Michelle's definitely involved in the mix somewhere, but whether she's capable of killing Frank, you'll have to wait and see. I think she could be!"
Coronation Street airs Frank's final episodes on Monday, March 5 from 7.30pm on ITV1.
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