Audrey suffers the shock health scare in the middle of another heated argument with her loved ones in an upcoming episode.
The Weatherfield hairdresser has recently been embroiled in battles with grandson David (Jack P Shepherd) over the salon, which continue to spiral out of control in the coming days.
Next Monday's (April 23) Coronation Street double bill sees Audrey serve David with an injunction in a desperate bid to reclaim the business. However, as a furious row ensues, Audrey collapses in pain.
A desperate Lewis (Nigel Havers) then cradles unwell Audrey in his arms, while David frantically dials 999 - worried that he's about to lose his gran for good.
United in their fears, Lewis, David, Kylie and Gail rush to the hospital to be at Audrey's bedside. Doctors later advise them that the next 48 hours will be crucial.
Coronation Street's production team and actress Sue Nicholls, who plays Audrey, have worked closely with the British Heart Foundation to ensure an accurate portrayal of the storyline.
Nicholls also spoke to women who have suffered heart attacks as part of her research for the emotional episodes.
Nicholls commented: "It was important for me to do this right and the British Heart Foundation have been a huge help to me. They kindly put me in touch with some ladies who had suffered similar attacks to Audrey, and it was really useful to be able to speak to them about their experiences.
"Many women will identify with Audrey's lifestyle - she works long hours, has little time to exercise and enjoys a tipple down The Rovers.
"After her heart attack, Audrey starts to think more about her heart health and lifestyle. I hope the women watching Coronation Street will think about theirs, too. The truth is it could happen to any one of us - it's not just middle-aged men who are affected."
The British Heart Foundation is now urging women to take an online test to see if their own lifestyle could be putting them at risk.
Doireann Maddock, senior cardiac nurse at the BHF, explained: "The sad truth is that almost 40,000 women die from heart disease each year and too many lives are lost to a killer which is largely preventable.
"Audrey is a seemingly fit and healthy woman, so this is a real wake-up call to all of us to 'think heart' and look after our health more.
"We're urging all women to take our online lifestyle check, it takes less than 10 minutes but could help make a big difference to your heart health in the future."
More information can be found on the British Heart Foundation website.
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Photo gallery - Audrey suffers a heart attack and is rushed to hospital.