Ryan Thomas (Jason Grimshaw), Brooke Vincent (Sophie Webster), Sue Cleaver (Eileen Grimshaw) and Ben Price (Nick Tilsley) will present the documentary, to be screened in July.
Michelle Keegan (Tina McIntyre) was also rumoured to be taking part in the programme, but is no longer involved according to ITV sources.
Corrie Goes To Kenya will feature the actors flying to the African country to visit struggling families and raise awareness about HIV in the country.
A production source said: "This trip will be a real eye-opener. The cast will come face to face with people whose lives could not be more different from their own.
"When you talk to people affected by these problems, the impact is huge. And the Corrie stars are desperate to help in any way that they can."