The salon, called Dollface, was opened by Shepherd and Lauren Shippey less than a year ago, The Mirror reports.
However, it closed late last year without warning, and the shop's Twitter page has now announced that the premises had to shut due to "unforeseen circumstances".
Shopkeepers in the neighbouring area of Wilmslow, Cheshire admitted that they had not known that the salon was closing.
One said: "They shut up before Christmas, I don't know why. They hadn't even been there a year."
Shepherd, who plays hairdresser David Platt in the ITV soap, will soon discover that his on-screen wife Kylie is pregnant.
Kylie actress Paula Lane recently revealed that "evil David Platt" could return once he discovers that he may not be the father of the child.
The 24-year-old has two children in real life, one with fiancée Shippey. The pair reconciled last year after it emerged that he had fathered a child with another woman. Get the Inside Soap magazine on your iPhone or iPad