The actress, who plays Roy Cropper's no-nonsense mother Sylvia Goodwin, recently filmed her character's departure.
Sylvia's exit scenes will air on screen this month, forming part of her daughter-in-law Hayley's cancer storyline, according to The Sun.
Writing on Twitter today (August 2), a Coronation Street spokesperson confirmed that Cole has finished filming "for the time being".
Cole was cast in Coronation Street in December 2010 and made her first appearance as Sylvia the following April.
Her major storylines have included bonding with Roy, facing up to the truth of Hayley's past, and finding love with wealthy Milton Fanshaw.
More recently, Sylvia has been supporting the Croppers following Hayley's pancreatic cancer diagnosis.
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