Tina and Tommy, Leanne and Nick, Marcus and Maria, Tyrone and Kirsty, and Michelle and Steve will be among the Weatherfield pairings who have big storylines over the coming weeks.
The new promo shot shows storm clouds gathering as the ten characters stand on the cobbles, hinting at difficult times ahead for all of them.
itv.com confirms that Tina will indeed become pregnant later this year as she goes ahead with her plan to have a baby for Gary Windass and Izzy Armstrong.
Tommy has always struggled with Tina's decision to help the troubled couple - and the situation could get worse as the idea becomes a reality.
Meanwhile, the future of Nick and Leanne's relationship has also been thrown into doubt. It's been revealed that Leanne will soon get her divorce papers through following her split from Peter, but she doesn't seem as happy about it as Nick.
The Corrie site teased: "When Leanne's sister and Nick's jealous ex-squeeze Eva discovers that there may be trouble in paradise, she hatches a plan to make it work in her favour - is this the end for Nick and Leanne?"
Elsewhere on the cobbles, Rob Donovan could prove to be a love rival for Steve McDonald when the cabbie becomes distracted by Tracy's antics and takes his eye off the ball with Michelle.
Also ahead, there are big consequences for Maria and Marcus in the aftermath of their kiss, while Tyrone remains fearful of Kirsty but is reluctant to leave her following her baby bombshell.
See the soap's full autumn preview here.
Coronation Street airs Mondays, Wednesdays and Fridays on ITV1. Get the Inside Soap magazine on your iPhone or iPad