Despite average ratings of over 6 million viewers, ITV has made the decision not to recommission the Yorkshire-based programme to make way for "new programme ideas" for its timeslot.
Over the years, the programme has played host to big names such as Sarah Lancashire, Pam Ferris, Denise Van Outen, Brian Capron, Philip Middlemiss and, more recently, Shobna Gulati.
An ITV spokeswoman said: "Where The Heart Is has been a very successful series for ITV1. But the decision has been taken in order to create some flexibility for new programme ideas in that 8pm Sunday slot alongside Heartbeat, The Royal and Wild At Heart."
Producer Ian Hopkins added: "I am sorry to have to announce that Where The Heart Is has been cancelled. I would like to thank you for all your support for the programme over the last 10 years."