Following the success of the mini drama's initial 12 episodes, the public broadcaster has ordered a further 10 for a second run.
Series two will focus on a fresh set of four yet-to-be-cast youngsters as they settle into Walford life living in the flat above Roxy's salon.
The episodes are to be penned by the 13 young writers who scripted the first series.
Speaking of the recommission, EastEnders' executive producer Bryan Kirkwood said: "It'll be very exciting to see where our brilliant young writers will take the next series and the evolution of a whole new set of characters.
"The cast have been a noisy burst of fun in EastEnders and provided the show with new faces that audiences have really engaged with."
Simon Nelson, controller of portfolio and multi-platform at BBC Vision, added: "We had no hesitation in commissioning another series, something which will delight the 17,000 fans who've been calling for more episodes on the E20 Facebook page."
Three of the four original E20 cast - Emer Kenny (Zsa Zsa Carter), Sam Attwater (Leon Small) and Ricky Norwood (Fatboy) - were immediately picked up for the main show, while Bunmi Mojekwu (Mercy Olubunmi) signed a similar deal just before the close of series one.
Series one is due to be repeated from Friday, April 23 at 8.30pm on BBC Three in three 30-minute outings, while the second series of 14-minute eps will be made available on the show's official website later this year.