Starting on September 14 at 1am, the sports broadcaster will carry live coverage of all American Football's Monday night matches, with coverage repeated the following day.
Every week, ESPN will also televise the 90-minute pre-game programme, Monday Night Countdown, in which host Chris Berman previews the evening's action.
"Monday Night Football is an enormous global sports franchise with an incredibly strong heritage, and it regularly features the very best NFL matchup of the week," said ESPN EMEA vice president of TV channels Jeroen Oerlemans.
"With the NFL's continued growth in the UK, this is another example of how we are building quality global programming around our core UK sports schedule."
NFL vice president of media strategy and development Hans Schroeder added: "We are pleased to expand our partnership with ESPN in serving our fans in the UK who are passionate about the NFL. ESPN will continue to do an outstanding job of bringing our fans closer to our sport in new ways."
ESPN has exclusively aired Monday Night Football in the US since 2006 and has attracted America's biggest ever cable TV audience when 21.8 million viewers tuned in to watch the Green Bay Packers versus the Minnesota Vikings on October 5 last year.