The app, titled ESPN Goals, features a basic service offering news and live scores, which is free-to-download. However, the full video clips package will cost either £3.99 a month or £29.99 for the whole season.
UK users will be able to access the app on Apple's iPhone or Google Android-enabled devices, along with ESPN's mobile site. The app will expand to other mobile services, such as Nokia's Ovi Store, in due course, reports The Guardian.
The application uses ESPN's recently agreed deal for mobile rights to all Premier League highlights for the next three seasons.
The sports broadcaster said that it is able to stream the goal highlights "usually within minutes of the action on the pitch", apart from during the "protected TV window" between 2.45pm and 5.15pm on Saturdays.
ESPN wants to position the mobile service as the best place to watch Premier League goal highlights before they are shown later on the BBC's Match Of The Day or Sky's Football First.
"Mobile media has seen dramatic growth in recent years and has proven to be a significant and important part of the way people connect to the sport they love," said ESPN International's vice president of digital media Tom Gleeson.
"ESPN Goals will serve as a fantastic complement to our television business in the UK."
For the 2010/11 season, ESPN will air 23 live Premier League games, along with 30 Scottish Premier League ties, 25 FA Cup games and 27 Europa League matches.
Earlier in the week, ESPN secured a deal to air 100 archive Premier League matches every season on ESPN Classic and its associated video on-demand platforms.