According to figures released today by the corporation, Matt Smith's debut as the Doctor in Doctor Who - The Eleventh Hour was iPlayer's most popular show this year, attracting 2.2 million requests. The programme was followed by the first episode of series 15 of Top Gear with 1.6m and Sherlock - A Study in Pink with 1.4m.
The on-demand service, which reaches its third birthday on Christmas Day, attracted a record-breaking 141m requests in November for TV and radio programming. It also pulled in a minimum of 100m requests for every month of the year.
Other popular shows on iPlayer in 2010 included the first episode of series three of comedy Outnumbered, which generated 1.16m requests, and the live episode of EastEnders in February, with 1.13m.
On radio, 5 Live's coverage of England's World Cup clash against Slovenia was the most popular programme, pulling in 317,000 requests. It was followed by Test Match Special's coverage of The Ashes in January and 5 Live Sport Extra's commentary on the World Twenty20 Cricket Final in May.
Daniel Danker, the BBC's recently-appointed general manager of on-demand programming, said: "BBC iPlayer has had a remarkable year - with well over 100m requests for programmes each month of 2010 and over 1.3bn programmes played through the year.
"In 2011 we will bring BBC iPlayer to even more licence fee payers, dramatically increasing our investment in BBC iPlayer on mobile and TV, and laying the foundation for an incredibly interactive London 2012 experience."
BBC iPlayer can now be accessed on around 40 different devices and services, including TV platforms, games consoles, mobile smartphones and connected TVs.
The BBC recently made the service available on Blackberry mobile devices, Sony's connected Bravia TV sets and the BT Vision digital TV platform.
On a weekly basis, each TV user on iPlayer requests just over four programmes and streams more than an hour of content. Each weekly radio user requests around five programmes and streams around three hours of content.
BBC iPlayer, recently voted the UK's most user-friendly catch-up TV service, also received an upgrade in May, incorporating social network functionality and links to other video on-demand websites.