Speaking on a Television Critics Association panel for the launch of Dustin Hoffman's new television series Luck on HBO, Nolte claimed that 3D TV "disconnects the eyeball, the lenses from the brain".
He appeared on the panel alongside Hoffman, Luck writer David Milch and Michael Mann, who directed the debut episode of the show.
Luck is due to premiere soon in the UK on Sky Atlantic under Sky's exclusive multi-million pound deal with HBO.
The drama will not air on Sky 3D, the first ever dedicated 3D channel launched in Britain in late 2010, which is a fact that will no doubt please Nolte.
The actor believes that long periods spent watching 3D television will cause health problems, according to The Hollywood Reporter.
"3D disconnects the eyeball, the lenses from the brain. It's like the brain itself is creating the hallucination of 3D," he said on the panel.
"They're going to find out six hours of 3D TV will cause psychotic breaks. Australia is doing the research. I can just tell you that."
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