A Toyota Prius, modified by the search engine giant, became the first driverless vehicle to hit the road when it took a cruise along the Las Vegas strip.
The car uses mounted cameras, radar sensors and a laser range finder to map out the position of other traffic. The car was previously tested on the roads of California, with a trained driver on board to override the software if necessary.
Google engineers reported that the vehicle covered 140,000 miles with no accidents, aside from a minor bump at traffic lights from a driver behind.
"They're designed to avoid distracted driving," Nevada DMV Director Bruce Breslow told The AP. "When you're on the Strip and there's a huge truck with three scantily-clad women on the side, the car only sees a box."
Nevada altered its laws to allow driverless cars in March. Under the legislation, two people must be inside the vehicle while it is in motion - one watching the wheel, and the other monitoring a computer screen displaying the planned route.
Google has applied to licence three test vehicles. Car companies are also seeking self-driven vehicle licences in Nevada.