During Facebook's second quarter earnings report Zuckerberg fielded questions from investors, including the possibility of a Facebook phone in development.
According to the CEO, a Facebook phone "really wouldn't make much sense for us to do".
Zuckerberg's comments go against recent reports that Facebook is working with mobile manufacturer HTC to create a Facebook phone, to be launched in mid-2013.
HTC has already established a close relationship with Facebook, resulting in HTC handsets that include a dedicated button giving direct access to the social network.
Facebook is available on all smartphone and tablet platforms, with the social network's mobile user base growing by 67% over the last year.
[L: Facebook on a mobile, R: HTC ChaCha handset, which features a Facebook share button]
However, while Zuckerberg has said that it might not make sense for a Facebook phone right now, he did not appear to rule out such a development completely.
"We want not just to have apps that people use, but be as deeply integrated as possible, where other apps can build on top of Facebook," he said in response to another question about Facebook on mobile.
A Facebook phone would give the social network that kind of deep integration, providing control over the device ecosystem.
With the recent announcement that Facebook generated $1.18 billion (£753 million) in revenue during its second quarter, the company would have the capital and momentum to further pursue a phone project if it wished to.