From mid-October, British customers can purchase the Nook Simple Touch and Nook Simple Touch With GlowLight devices at Barnes & Noble's online UK store, as well as browse the 2.5 million eBooks and other content on the dedicated Nook Store.
This marks Barnes & Noble's first expansion outside of the US market, where the firm has built a solid presence against Amazon's dominant Kindle range.
Nook devices are currently sold in the US at Nook Digital Shops and in more than 1,300 Barnes & Noble and Barnes & Noble College Bookstores, along with US retailers.
The Nook will again take on the Kindle in the growing British eReader sector, but also compete with Kobo devices and the Sony Reader range, which recently expanded to a new model.
Barnes & Noble intends to partner with leading UK retailers to offer the eReaders both in-store and online. Pricing and exact availability will be announced in the coming weeks.
"We are proud to be able to offer our top-rated line of Nook reading devices and our award-winning digital bookstore to the discerning and highly educated consumers in the UK," said William J. Lynch, the chief executive at Barnes & Noble.
"We're confident our award-winning technology, combined with our expansive content - including books, children's books, magazines, apps, movies and more - will bring UK customers the option they've been waiting for."
The Nook Simple Touch is a lightweight device that features a WiFi connection and e-Ink technology for reading even in bright sunlight. Glowlight is patent-pending lighting technology for comfortable reading while in the dark.
Any content purchased from the Nook store, including books, newspapers, magazines and comics, is stored in the Nook Cloud.
Earlier in the year, Microsoft invested $300m (£184m) in a new venture from Barnes & Noble intended to "accelerate the transition" from physical books to e-reading.