The broadcaster has acted to "future proof" its online presence with the new responsive technology, which essentially resizes and reorganises the content for the specific platform on which it is being viewed, such as smartphones and tablets.
The redeisgned site is also now prepped for "future innovations" such as converged TV, said Channel 4.
ITN, which produces Channel 4 News, said last month that it intended to adopt responsive design on its video site. But it is thought that no current UK news programme has so far adopted the technology online.
Alongside gearing its website for the multi-platform future, the adoption of responsive content should enable Channel 4 News to appear more prominently in the web search rankings.
Google recently indicated that sites that serve all connected devices via the same set of URLs are more likely to be indexed on the search rankings, as well as linked to and shared by users.
"We are the market leaders in experimentation with news content, and this investment will ensure we remain at the forefront," said Vicky Taylor, the commissioning editor of new media, news and current affairs at Channel 4.
"We have to ensure that our news, commentary and analysis is available on any device - those that are available now - but also those that are currently in development."
Online blogs such as Jon Snow's Snowmail and Cathy Newman's award-winning FactCheck will remain key features on the site, and there are new blogs for international editor Lindsey Hilsum, social affairs editor Jackie Long and health & social care correspondent Victoria Macdonald.
Liam Dutton's weather site is also more closely integrated via a personalised homepage widget
Special Reports remains available, showcasing major investigations into topics ranging from disabled access on public transport to the Sri Lankan civil war.
Designed by ClearLeft, the new site has a 'live from the newsroom' rolling blog offering constantly updated multimedia content, while the 7pm news programme on Channel 4 can be live streamed through the site, or watched via catchup.
Channel 4 acting head of online Anna Doble said: "This is a fantastic way of combining the lively social media activity of our team with the brilliant journalism they produce in a live, dynamic feed.
"It will make the most of our content, and ensure that our relationship with users and viewers continues to extend beyond the 7pm programme. It will also mean we are better placed to respond to breaking news online."