Zuckerberg, who founded Facebook in his college dorm room in 2004, also yesterday (September 11) spoke for the first time about the firm's troubles since it listed on the US stock market in mid-May.
The current share price is almost half the $38 debut price for the firm's blockbuster initial public offering (IPO).
He said that the big slide in the social network's stock was "disappointing", but suggested that he is looking to a bright mobile future.
Speaking at the TechCrunch Disrupt conference in San Francisco, Zuckerberg hinted that Facebook would look to make most revenue from its smartphone apps rather than its desktop service.
"Over the next three to five years, the biggest question on everyone's mind is really going to be how well Facebook does with mobile," he said.
Earlier in the year, Facebook launched native mobile apps for Apple's iOS smartphones and handsets running Google Android.
This has led to unease amongst investors over whether Facebook, the only US company ever to debut with a $100 billion valuation, can truly capitalise on mobile.
Zuckerberg told the conference that ads have to be "more integrated into the product on mobile", and joked that everything he does "breaks", but he acts to fix it "quickly".
Facebook has been rumoured to be working on creating its own smartphone as part of a supposed strategy to gain greater control over the mobile ecosystem.
But Zuckerberg again rejected the speculation, and pointed to the site's already massive reach around the world.
"If we make a phone we could get maybe ten million users? Twelve million users? That doesn't move the needle for us," he said.
"Building a phone is the wrong strategy for us."
"There are tons of people that are super-pessimistic," Zuckerberg said.
"I would personally rather be underestimated. It gives us latitude to go out and make some big bets."
One of those "big bets" is the acquisition of Instagram, the photo-sharing app that has more than 50m users across iOS and Android devices.
Facebook recently completed its $700m+ buyout of the two-year-old startup, and intends to keep the app going as an independent service, but also harvest the talent of its team to create winning mobile experiences.
Zuckerberg owns 444m Facebook shares, which are each valued at $19.43 on Tuesday's closing price. He also holds the option to issue another 60m.
However, he has seen some of his key early backers recently sell shares, including PayPal co-founder Peter Thiel, one of Facebook's earliest investors, who has sold the majority of his stake, earning him more than $1bn.
Facebook co-founder Dustin Moskovitz has also sold shares, although he still holds a significant stake in the world's largest social network.