The online retailer is no longer selling the large-screen edition of the device in the US or abroad as it channels its resources into the recently announced Kindle Paperwhite models.
Amazon's e-reader line now includes the ad-subsidised entry level Kindle, the mid-range Kindle Keyboard 3G and the Paperwhite and Paperwhite 3G.
The retailer is yet to issue an official statement on the delisting of the Kindle DX, but has been gradually reducing its price in what was likely an attempt to clear out remaining stock.
Amazon announced last week that it does not profit from its hardware as its business model relies almost entirely on software sales.
Amazon will launch its Kindle Paperwhite e-reader in the UK this month after making its 200,000-book Lending Library subscription service available to UK Kindle owners in the territory.