Touted as a competitor to the Samsung Galaxy Note 2, the 5-inch handset is a repacked version of the HTC J Butterfly for the Western markets.
HTC's DNA - revealed by evleaks - is expected to feature identical specs to the Japan-only J Butterfly, meaning it will boast a 5-inch display with a more powerful resolution than both the Samsung Galaxy S3 and iPhone 5.
The Super LCD 3 screen is capable of displaying imagery in 1080 x 1920 with a 440ppi density. Apple's iPhone 5 can only manage 640 x 1136 at 326ppi, while the Samsung device offers 720 x 1280.
It is likely to be powered by the same 1.5GHz quad-core processor with 2GB of RAM on board, and run Google's Android 4.1 Jelly Bean operating system out of the box.
Other features could include an 8-megapixel camera capable of shooting 1080p video, a front-facing snapper with a 2.1-megapixel sensor, and Wi-Fi, Bluetooth 4.0, 4G and microSD support.
The HTC DNA has been tipped for a December release in the US, with a UK launch likely to follow shortly after.