Passengers on the same plane as McAfee confirmed to Reuters that the computer software pioneer landed in Miami at around 7pm local time on Wednesday evening (December 12).
Eyewitnesses claimed that he was escorted from the plane by airport security officers.
McAfee is wanted for questioning as a 'person of interest' in Belize regarding the death on November 10 of his neighbour Gregory Faull, a fellow US expatriate.
The 67-year-old was arrested at the Intercontinental Hotel in Guatemala City last week on suspicion of entering the country illegally from Belize.
McAfee has denied any wrongdoing and has expressed fears for his life if he is handed over to Belizean authorities, who have said that he is not a prime suspect in the investigation.
He also recently appealed for information to help clear his name, offering a $25,000 (£15,500) reward to anyone who catches Faull's killer.