The free app allows users to keep up to date with current programming, as well as access an archive of content spanning the last 30 years.
"We're very excited to be working with Microsoft, a strong global brand which aligns perfectly with Channel 4's engaged ABC1 16 to 34 audience," said Channel 4 group digital manager Michael McSharry.
"It demonstrates how we can work with clients collaboratively to create something that is new to market, bespoke and one that utilises all our 4oD platforms as well as linking in to relevant content on Channel 4 to provide a fully integrated cross media brand experience."
The move sees Channel 4 become the first major UK broadcaster to support the operating system with a native app, getting in ahead of the BBC.
"As the first UK video on demand app for our new Windows 8 platform, we love the way Channel 4 is bringing Windows 8 to life with its 4oD app," said Microsoft's Anand Krishnan.
"It is creative apps such as this that will continue the great momentum and excitement around Windows 8."
Microsoft last month announced that its new Windows 8 operating system had claimed more than 40 million users in its first month on the market.