The cable operator, recently bought by US media giant Liberty Global, has also confirmed that it will offer the new Sky Movies Disney channel announced today by Sky.
YouTube is already an app on Virgin's TiVo service, but now a specially-created channel (198) will offer subscribers access to the Google-owned video sharing network direct from the TV guide.
Virgin says that this is the first time in the UK that a non-traditional broadcast channel has been listed alongside the likes of BBC One, ITV, and Sky1.
Virgin Media has also more closely integrated YouTube clips and channels into TiVo's My Shows and Search and Browse areas.
Peter Chapman, associate director of content acquisition at Virgin Media, said: "The distinction between different types of entertainment - from channel schedules to on-demand TV, from linear broadcasts to online content - is blurring all the time.
"By giving YouTube a place in our channel listings we're breaking the mould of the traditional EPG and giving our customers even more choice in how they can watch the great content on our platform."
YouTube's global director of platform partnerships Francisco Varela added: "We're always looking for new ways to bring the exciting content generated by our creator community to viewers and are delighted that the YouTube app now has a place in Virgin Media's channel listings."
Virgin Media has also today confirmed that it will offer the new Sky Movies Disney channel from its launch in late March, as part of the Sky Movies offering. The channel will broadcast new and classic Disney movies on pay-TV.
> YouTube to roll out on UK free-to-air TV via Freesat deal