Rich Hall keeps his regular place and is joined by Seann Walsh, Sara Pascoe, Josh Widdicombe and Paul Chowdhry, who take turns to give their comedic thoughts on things. To mark his start as the main man, Digital Spy got on the phone and spoke to Jon about the show, edgy material and his problem with Sir Philip Green.
How different will it be to host Stand Up For The Week?
"I'm looking forward to it really. I'm not daunted because I spent a lot of time compering on the circuit, so I'm used to hosting gigs. It just means I get a wider remit of things I can talk about, which is a huge benefit for me. I was tied to sport last time, whereas this time I can pretty much talk about what I like."
Do you hold back when you're hosting to let the featured acts steal the show?
"I wouldn't say I ever hold back. There are things I wouldn't do when hosting, like get people up on stage or get the audience doing a sing-song or something like that. That's pretty difficult to follow if you're just going to come out and speak quite softly about something that happened in Libya that week. So I would seek to rabble-rouse, but I have absolute faith in everyone who's on the show, so I won't be patronising them by holding back at all."
The show always has a woman among the regulars. Is it important to have female stand-up represented?
"It's important on a show that's topical that if you're going to cover topics properly, you cover viewpoints from different angles. That means making sure you have a spread of ages, a spread of sexes and a spread of backgrounds so there's not just four blokes in their early 20s talking about Westlife splitting up and doing some cheap gags about that."
You're also now a team captain on 8 Out Of 10 Cats - do you prefer panel shows or straight stand-up?
"8 Out Of 10 Cats is a bit less stressful for me because you know that you've got Jimmy Carr and Sean Lock as your wingmen, so that anything you say that perhaps isn't quite finished, you've got two of the best comics in the country to help you.
"I feel like I need to do both. I need to keep my ad-libbing skills honed and make sure I'm able to banter with people and treat topics a bit more light-heartedly. But as a stand-up first and foremost my job is to make sure that I can write the routine that hopefully people will talk about when something big happens."
Your Philip Green comments on Have I Got News For You really hit that mark...
"The Philip Green thing was a point of such clear anger to me. It was so clear in my mind what was right and what was wrong. For me it's definitely wrong that if you're a billionaire you don't pay a lot of money back into the pot.
"A lot of people who go on to make a lot of money quickly forget where their education came from - and the roads and the hospitals that allowed them to get to a point where they earned that money. They delude themselves."
Do you think there's enough overtly political comedy out there given the current state of things?
"Politically it's a difficult time because it's not always easy to identify what the problem is. I will only ever go into a rant like that if I'm clear in my mind what the solution is. I don't like the weaker end of political comedy which is just saying, 'Something bad has happened and it would be better if it hadn't happened'. I don't think it really helps anyone.
"It's like the protesters outside St Paul's now. You need to at some point have an alternative solution otherwise people don't get behind you. If I had a choice I would rather watch a comedian not involve themselves in politics at all but be hilarious, than someone who doesn't really know what they're talking about getting on their soapbox and complaining."
Will the BBC cuts have a negative effect on comedy?
"Comedians should be okay because it's a fairly cheap form of entertainment. At its essence, you just need a camera to film someone who is good at what they do. If you film that well it's not really an issue of budget.
"My concern at the BBC is when it's afraid to defend itself on edgier grounds - where it's safer to make something that doesn't need defending. A sitcom set in a zoo on the moon is always going to be easier than giving a comic six half-hours to do something that might upset people and then have to defend themselves."
Regarding compliance, how do you feel about the storm over Ricky Gervais's use of the word 'mong' and what comedians can or can't say?
"At its core, you have to say there's no such things as should or shouldn't or can or can't. If Ricky Gervais wants to use that term, then that's up to him. And if people want to stop buying his DVDs as a result then that's up to them.
"I would never say it's a matter of what people can and can't say. My personal opinion is that I don't ever do jokes that are about disability or cancer or what are seen as 'edgier' topics. I've been affected by those things myself and I think that comedy should be a safe place for people. It doesn't mean you can't discuss important things, but I would never do a joke about cancer just because I don't think any joke is funny enough to justify upsetting someone who is going through that.
"Even if it's one person in an audience of a million. I, as a person, just simply can't justify making someone's life worse for the sake of a routine. I tend not to talk about those things. But that doesn't mean it's not other people's decision if they want to."
Your book It's Not Me, It's You was billed as a relationship guide from someone who's been single for seven years - are you still single?
"That's the noise that my brain is constantly making. My brain is constantly saying, 'Oooh! Oooh wow, this is interesting'. I've been seeing someone for a few months."
A lot of YouTube comments seem to be about how you're much too lovely to be single...
"I have to be careful because my act has basically become 'being slightly pathetic' over recent years. I would rather people judged me as a comic than as a potential date!"
Are you tempted to release a proper comedian's memoir?
"No, not remotely. I'm 29 years old. I think it would be an admission of defeat to think that the most interesting things in my life had already happened. I mention that briefly at the beginning of my own book, that I don't intend to write my autobiography till I'm in a potting shed at the back of a garden with a dog in about 30 years' time."
Stand Up For The Week returns this Friday at 11.10pm on Channel 4