A host of celebrity guests will fill the role of team captain in his stead. They include Mark Ronson, Frank Skinner, Dermot O'Leary, Jack Dee, Johnny Vegas and Bob Mortimer.
Bailey, 44, who had been on the show since 2002, has stepped down because of other work commitments.
The show's producer, talkbackThames, told The Press Association: "After 11 series selflessly, heroically and hilariously captaining one side on Never Mind The Buzzcocks, other commitments have sadly led to Bill Bailey being unable to take part in the forthcoming series of the hit comedy pop quiz."
Simon Amstell will return to host the quiz, which launched in 1996 and is one of BBC Two's longest-running shows.