Tony Stonem's younger sister Effy (Kaya Scodelario) and her best friend Pandora (Lisa Backwell) will be the only existing cast members to appear in the third series next year.
The new additions to the girls' lineup are Katie and Emily, twins with contrasting personalities, and the idealistic Naomi.
The boys are comprised of the charismatic Cook (Jack O'Connell), skateboarding stoner Freddie, magician J.J., and Thomas, who struggles to settle in the UK after arriving from Congo.
Harry Enfield, Morwenna Banks and Geoffrey Hughes will return for guest appearances, along with new guest stars Scott Mills, Mackenzie Crook, Sally Phillips and James Fleet.
Skins returns to E4 for a ten-episode run in January.