The BBC One quiz show, which features celebrity teams attempting to squeeze their bodies through unusual shapes in a moving wall, will return for ten episodes later this year.
However, Du Beke, 42, who was a team captain for the first series, will now present the show.
"I am completely thrilled that I will be presenting the series," he told The Sun. "My only disappointment is that I won't be wearing the silver suit this time around, although you never know!"
Cricketer Darren Gough, who was the second team captain, has also departed the programme. I'm A Celebrity... champion Joe Swash and rugby star Austin Healey are the new team captains.