The presenter was joined by joined by a host of celebrities and former This Morning contributors during today's show, which featured several montages of her most memorable moments.
"I couldn't have worked with a nicer team than all the people sitting here today and all the cameras, the sound men, everybody who brings cups of tea! There isn't a person in this building that I don't love," she said.
Among those who turned out to celebrate her final show were Matthew Kelly, Jenny McAlpine and John Barrowman, who opened the programme with a performance of Frankie Valli's 'Can't Take My Eyes Off You'.
Ricky Gervais, Alice Cooper, Danny Dyer and former show host John Leslie were among the stars who left video messages, with the latter also performing a piano version of 'My Way' and toasting Britton with champagne.
After being presented with a specially engraved bench for her garden, Britton said: "I can't believe all these gifts and surprises. I've had the best party that a girl could ask for!"
She ended the show by telling her tearful co-host Philip Schofield: "You have given me the best six years together. We've had a ball and good luck."
Finally, Britton was accompanied from the studio by husband Phil Vickery, while the production team lined the corridors to say goodbye and Michael Ball performed 'Cabaret'.
The presenter confirmed that she was stepping down from the ITV show in March. It was recently announced that Dancing On Ice host Holly Willoughby will replace her starting in September.