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The actor, who played Rodney himself in the long-running sitcom, will be joined by Inbetweeners star James Buckley, who will play the young Derek Trotter in Sex, Drugs & Rock 'n' Chips.
John Sullivan said: "Nick Lyndhurst is a comedy genius and I can't think of anyone better suited to bring the shady but charming Freddie Robdal to life.
"James Buckley has a tough act to follow but is sure to do for leather bomber jackets and winkle-pickers what David Jason did for camel-haired coats and cocktail umbrellas!"
Other stars cast in the 90-minute special include Kellie Bright as Derek and Rodney's mother Joan and Phil Daniels as their grandfather Ted.
The prequel will concern the release of Robdal from prison, which will "ruffle some feathers in the Trotter household".
The one-off episode will also feature teenage versions of characters Boycie, Trigger and Denzil.
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