The Sunday Express claims that Aniston will produce and star in the weekly programme, which will be broadcast on the Oprah Winfrey Network.
Aniston reportedly decided to work on a television show after being inspired by her friend Chelsea Handler, who hosts Chelsea Lately.
"Jen became fascinated with the format after spending time with Chelsea," a source said. "When she saw Oprah she mentioned that it would be fun to do a chat show and Oprah seized the moment and suggested they front one together for her new network."
The insider added that Aniston doesn't know how much she will be paid for the programme.
"Her salary is yet to be determined," the source said. "She is doing this for one reason only - she absolutely wants to do it."