The mockumentary, titled Cast Offs, follows six people with disabilities who have been sent to a remote British island for a fictional reality TV show.
The miniseries stars disabled actors Victoria Wright, Kiruna Stamell, Peter Mitchell, Sophie Woolley, Tim Gebbels and Mat Fraser. Their disabilities range from cherubism to blindness.
Commissioning editor Camilla Campbell said of the series: "I’m enormously excited to be working on a show that feels as ground breaking as Cast Offs.
"With the fantastic talent behind and in front of the camera, this confirms Channel 4’s commitment to bold and distinctive programming."
Cast Offs will air in an 11pm slot on Channel 4 in November.