The three-part serial, written by Stephen Butchard, follows the Ipswich murders and subsequent police investigation in 2006.
Jaime Winstone, Eva Birthistle, Natalie Press, Juliet Aubrey, Aisling Loftus, Kate Dickie, David Bradley, Lisa Millet, Ruth Negga, Kristen Wareing and Al Weaver have also landed parts.
Butchard said of the drama: "These five young women, precious to their families, had heart, ambition and potential; until an event or events, one wrong turn, one chance meeting led them into the world of heroin and crack.
"Their dependency on these drugs facilitated their easy exploitation and led them to the street. Our hope is that this drama provides a glimpse of the real girls their families knew."