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The 52-year-old is thought to be close to signing a £1 million, two-year deal with Channel 4 for the popular teatime programme.
A source told The MIrror that the former This Morning presenter is considered to be "the perfect replacement".
"The viewers love her because she is so bubbly and charismatic. And, just like her predecessor, she isn't reliant on the autocue," the insider said, adding that Britton's debut is likely to be in the spring if the deal goes through.
Britton, who is married to TV chef Phil Vickery, left This Morning in July after ten years.
The final episode of The Paul O'Grady Show aired in December, with the Birkenhead-born star leaving to launch a new Friday night programme on ITV1.
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