EastEnders stars Dean Gaffney and Louisa Lytton, Coronation Street's Jennie McAlpline, Boyzone's Keith Duffy, GMTV presenter Michael Underwood and Saturdays star Frankie Sandford will compete in the programme, which has been billed as the "ultimate celebrity endeavour contest".
Each contestant will venture through 'the door' and undertake challenges, which force them to face their fears. The celebrities will "battle claustrophobic spaces, suffer shocks and have to cope with a relentless barrage of disorientating games" as they compete for charity.
"The Door is a celebrity's worst nightmare! It's going to make great viewing," said Holden.
After the first show, three celebrities will enter the final, while the three losers will face a last ordeal. One of the losing three can earn a place in the second show during the final task.
The Door will air on ITV1 in late spring.