The star, along with Alex Ferns and Russell Grant, attempted to cook a set menu for 25 paying customers as part of the programme's culinary challenge. Each contestant then faced a score out of 100, which was decided by both the diners and host Marco Pierre White.
Ferns won the night with 62 points, ahead of Smillie's 40 and Grant's 41. From the bottom two, White chose Smillie to go home.
"To be honest I'm a bit gutted. I hate to be the first out of anything," she said following her exit.
Ferns and Grant now join Tupele Dorgu, Ruth Langsford, Nancy Dell'Olio, Elen Rives, Debra Stephenson and Donna Air in the semi-final.
Marco's Kitchen Burnout continues next Friday at 9pm on ITV1.