The Grey's Anatomy star will team up with David Morrissey for an adaptation of a Mark Billingham novel.
Oh will play DS Sarah Chen in thorne: scaredy cat, which follows the Metropolitan police as they investigate a number of murders in London.
The drama is part of a six-episode series which begins with thorne: sleepyhead. Other cast members include Sherlock Holmes star Eddie Marsan and Queer As Folk's Aidan Gillen.
Sky1's commissioning editor for drama Huw Kennair-Jones said: "We're thrilled to have an actress of Sandra Oh's calibre join David Morrissey, Aidan Gillen, Eddie Marsan and the rest of the amazing cast for the thorne adaptations as they bring Mark Billingham's iconic characters to life on Sky1 HD.
"thorne: scaredy cat promises to be a gripping, multi-faceted drama that'll complement thorne: sleepyhead perfectly, promising to make the thorne series an unmissable addition to Sky1 HD's ambitious drama lineup."
thorne: scaredy cat is expected to air on Sky1 and Sky1 HD in the autumn.