Love Bus will see contestants only have the time before the next coach stop to impress or convince their date. If they fail, the driver will throw them off at the nearest hospital.
Salmon said in a statement: "I am thrilled to be presenting this fun and innovative show for Fiver. I'm looking forward to touring the country in our routemaster Love Bus, finding love matches for singletons in far-flung places. It's set to be one exciting ride!"
Jeff Ford, who manages Five's digital channels, added: "I'm delighted to have secured this unique, upbeat format for Fiver. It's a refreshing approach to the dating game, and Zoe is the ideal host for this vibrant series."
Love Bus, produced by Carbon Media, will run for ten 30-minute episodes from the autumn.