Speaking to What's On TV, the comedian and former Never Mind The Buzzcocks host also responded to suggestions that his new project Grandma's House is a "Jewish" version of the '90s show.
He said: "For me The Royle Family was the last really good family sitcom. If people want to describe it in this way it's fine, but it's odd.
"Jewish seems less relevant to me than a conflicting family with an anxious person visiting every couple of weeks and trying to fix them.
"It feels very strange for it to be classified in this way. For me it's about acceptance, not about being Jewish."
Grandma's House, which sees Amstell play himself, starts tonight at 10pm on BBC Two.