Paul O'Grady Live! is billed as a "lavish new entertainment show and a perfect part of the weekend".
The hour-long show will feature "some of the world's biggest stars" and O'Grady will interview "home-grown talent including his favourite soap stars".
"There will be crazy games, stunts and big song and dance routines as well as few special surprises and Paul will be touch with viewers across the land live via Skype," the network confirmed.
Sir Tom Jones will be among O'Grady's guests on the first show. The presenter will also make his "acrobatic debut" alongside Britain's Got Talent winners Spellbound. More guests have still to be confirmed.
O'Grady's return to ITV was confirmed last year following a dispute which saw his Channel 4 chatshow come to an end.
Paul O'Grady Live! will begin on Friday, September 10 at 9pm on ITV1.
> Paul O'Grady ITV show details revealed