The actor will play Gabriel Monroe, a neurosurgeon who must contend with two new trainees, as well as a series of medical emergencies.
Mistresses star Sarah Parish will also appear in the series as cardiac surgeon Jenny Bremner, while Bouquet of Barbed Wire actor Tom Riley will portray anaesthetist Dr Laurence Shepherd.
Wallander actress Sarah Smart and former Teachers star Shaun Evans will also play guest roles in the first episode.
The series has been written by Peter Bowker and will be helmed by Sherlock director Paul McGuigan.
Filming on Monroe will begin this week on location in Leeds.