The Channel 4 programme will see the Big Brother host face praise and comedic insults from a wide range of celebrity guests.
Comedians who have signed up for the show include Rich Hall, Debra Stephenson, Patrick Kielty, Ed Byrne and Jack Whitehall.
Meanwhile, Chris Moyles, Dermot O'Leary, Julian Clary and Fearne Cotton will appear at the event alongside former Big Brother contestants Brian Dowling, Nikki Grahame, Sophie Reade, Brian Belo and Sam Pepper.
McCall said: "I'm honoured [and] terrified at the thought of being roasted - I think I'm going to have the night of my life and laugh lots at my own expense. I can't wait!"
Davina McCall: A Comedy Roast, which will be hosted by Jimmy Carr, airs on Friday, October 15 at 9pm on Channel 4.