The E4 show, which is currently called Noel Fielding: Boopus, will feature sketches, characters, art and animation.
The series is said to be in Fielding's "singularly bizarre, fantastical and magical style" and will feature several special guests.
Fielding will also produce the show with a number of collaborators, including Kasabian star Serge Pizzorno.
"I want to make something in the spirit of Spike Milligan or The Kenny Everett Show but using modern techniques," Fielding said. "Blending filmed comedy with animation. Television needs a madman! I want the show to be psychedelic and beautiful but have charm and personality. If Dali made a show, hopefully it would look like this."
The series is expected to air next year on E4.