The pair will face off against each other for the award, along with David Jason for A Touch of Frost and Philip Glenister for Ashes to Ashes.
Their respective series have also been nominated for Best Drama along with Shameless and Waterloo Road.
Elsewhere, X Factor host Dermot O'Leary has been nominated for the first time in the Best Entertainment Presenter category, alonside Ant & Dec, Davina McCall and Paul O'Grady.
The X Factor will face Britain's Got Talent, Dancing on Ice and Strictly Come Dancing in the Best Talent Show category.
Coronation Street is up for Best Serial against EastEnders, Hollyoaks and Emmerdale.
The nominations in full:
Best Drama Performance: Benedict Cumberbatch (Sherlock), Matt Smith (Doctor Who), Philip Glenister (Ashes to Ashes), David Jason (A Touch of Frost)
Best Drama: Doctor Who, Shameless, Sherlock, Waterloo Road
Best Serial Drama: EastEnders, Coronation Street, Hollyoaks, Emmerdale
Best Serial Drama Performance: Katherine Kelly (Coronation Street), Steve McFadden (EastEnders), Danny Miller (Emmerdale), Lacey Turner (EastEnders)
Best Entertainment Programme: Big Brother, I'm a Celebrity... Get Me Out of Here!, Mock the Week, QI
Best Entertainment Presenter: Ant & Dec, Dermot O'Leary, Davina McCall, Paul O'Grady
Best Talent Show: The X Factor, Britain's Got Talent, Strictly Come Dancing, Dancing on Ice
Best Comedy Programme: Benidorm, Harry Hill's TV Burp, Michael McIntyre's Comedy Roadshow, Outnumbered
Digital Choice: Glee, Peter Andre: The Next Chapter, The Inbetweeners
Best Factual Programme: Celebrity Masterchef, Junior Apprentice, Top Gear, Who Do You Think You Are?
Best Topical Magazine Programme: BBC Breakfast, Loose Women, This Morning
Best Newcomer: Olga Fedori (Holby City), Paula Lane (Coronation Street), Ricky Norwood (EastEnders), Marc Silcock (Emmerdale)