The Peep Show comic said that he hopes the interviews would provide an alternative approach to political journalism usually found on TV. According to The Guardian, Downing Street have agreed to offer ministers to appear on the show after holding discussions with the programme's producers.
Speaking about his interview style, he said: "I think you've got to allow people to talk. I think too much of political journalism is thoughtlessly scrutinising. It's always about contradicting the thing they've just said and crucially finding the difference of opinion they may have had with someone else they work with. Apparently, that's what you get 1,000 points for.
"We know those disagreements exist. So what have we done by getting them to agree it? It's just like getting someone to admit that they snore. It doesn't really mean anything. That very approach to interviewing them leads them to say less and become more boring and more unwilling to engage. It's a vicious circle."
He added: "There's a live audience so the politicians will be less inclined to be boring. A lot of the pressure of the Paxmanesque approach is, 'we just let this guy talk and blather on for ages along the party line'. I don't think that will come across well on this show."
10 O'Clock Live, which will be hosted by Mitchell, Charlie Brooker, Lauren Laverne and Jimmy Carr, kicks off on Thursday at 10pm on Channel 4.