The Total Wipeout host admitted that she had been in a similar position when she joined Channel 4's The Big Breakfast following Denise Van Outen's and Johnny Vaughan's exits.
"Well I think Christine is a tough chick," the Irish presenter told Digital Spy. "She's very intelligent and very competent and very good at what she does. I know she'll weather this particular storm and is respected for what she does professionally.
"She's with ITV as a whole now, it's not like this is the be all and end all of it. There's rumours of her doing The X Factor and I know ITV really, really nurture their talent. She'll be having that kind of conversations with the network, her agent and production companies. Behind the scenes, whereas it might look really bad to everybody else thinking 'poor Christine', I'm sure she's absolutely fine and that there is other stuff being talked about. She's really good at what she does."
However, the 37-year-old acknowledged that taking on such a role can be like drinking from a "poisoned chalice" due to the comparisons which will inevitably be made.
"It's always lovely to see a fellow Irish woman doing well and I think this is what I'm talking about - the poisoned chalice, the dreaded poison chalice," she said. "There will always be comparisons and you take a risk when you do that kind of stuff. Ultimately, for most of them it's worth taking that risk - to either learn lessons from it or to propel yourself to do something completely different."
She continued: "She'd done The One Show for a very long time, she wanted to go with Adrian [Chiles] whose obviously a good friend and they work really well together. It's a shame for both of them that there is such bad press. The press love to knock people down! That style of presenting, letting everybody in on what is happening behind the scenes, there's not enough of that. That's very Big Breakfastesque and I take my hat off to them for doing that.
"I also have to say, I take my hat off to them for every piece of stuff that has been said about them in the press that has been negative. I know how hard that is to take. I know how difficult it is to wake up in the morning at 3am, get into a car and go to a job that you know people are watching going, 'I'm going to write something bad about this'.
"For them to get there and have that smile on their face and go 'F the begrudgers', I think that says so much more about them - rather than them going around and saying, 'I'm not doing this anymore, I'm quitting'," she added. "With a smile on their faces they are almost sticking two fingers up at people saying, 'Look there's nothing else we can do but do our job here'. And that's what they're doing so fair play to them!"
> Click here to read the full interview with Amanda